Schaefer a Nanoinnovation 2020 - 15-18 Settembre 2020

Abbiamo piena confidenza nella nostra offerta tecnologica, desideriamo presentarvela e discuterne con voi. Qui sotto i titoli e gli abstract delle tre presentazioni che terremo al Nanoinnovation2020. Vi invitiamo a partecipare, e se avrete qualche domanda da farci, saremo ben lieti di rispondervi, sia al termine della presentazione che al nostro stand.

• Relatore: Paolo Bariani, Dr. Ing. – Schaefer South-East Europe srl
  3D Optical Metrology Techniques: Fringe Projection, Confocal, Ai Focus Variation, Interferometry
  A 3D optical profiler is a non-contact measuring instrument that captures the surface topography in x, y and z directions, with a system noise that can go down to subnanometers and a lateral resolution in the range of 160 nanometers up to 1 micron. There are few optical techniques designed for 3D optical metrology. Among the most successful and well-known nowadays in the industry are the Confocal, Interferometry and Focus Variation. Each of them has its own advantages and drawbacks. In this talk we will go over each of them and highlight the main applications for each.

• Relatore: Francesca Sbrana, Ph.D – Schaefer South-East Europe Srl
  Label free imaging of nanoparticles in cells with Enhanced Darkfield Hyperspectral Microscopy
  The ability to observe and to characterize nanoparticles without any fluorescent labeling or other sample preparation is critical in a wide range of biological research field such as nanotechnology -drug delivery research, nano toxicology research and nanomaterials synthesis research. The enhanced darkfield hyperspectral microscopy enables an easy and effective way for real time observation of nanoparticle uptake in live or fixed cells and in ex vivo tissue sections. The principles of Cytoviva patented enhanced darkfield hyperspectral microscopy, specifically designed to enable rapid, label free imaging of nanoparticles in biological or materials based environments will be presented. Examples of nanoparticle interactions with live cells, tissue and other materials will be shown.

• Relatore: Marianne Marchioni, Ph.D - Izon Science Ltd
  Standardized Single Particle Measurement of Number, Size and Charge is required for Confidence in Nanomedicine Engineering and Development
  The heterogenous nature of nanobiological particles means that obtaining individual particle data is essential in order to gain a true understanding of the sample. However, light-based techniques (such as DLS or NTA) provide solution-averaged data and individual particle measurements can be difficult, requiring extensive sample preparation and laborious measurements. There is an urgent need for fast, accurate, and simple techniques that can provide reliable single-particle data.
  The new TRPS-based technology that Izon Science has developed, called Exoid, is the solution that researchers have been waiting for. Incorporating the unparalleled accuracy of TRPS into a semi-automated machine with improved sensitivity and usability represents a reliable method of measuring individual particles.
  TRPS offers the level of detail and certainty that the medical world requires. The importance of showing size and number is now well understood. Current developments are aimed at increasing the accuracy and resolution of TRPS single particle charge measurements by a factor of 10.
  The extracellular vesicle research community is beginning to make advances using extracellular vesicles, mainly exosomes as a new class of therapeutics or biological markers. There are a number of different configurations including gene therapy, drug delivery and stem cell derived exosomes. These are biological particles, typically more heterogeneous than synthetic particles and typically more adapted for survival in the body than synthetics such as liposomes. The need for precise and standardized isolation, measurement and downstream analysis of these nano-bio structures provides some additional challenges which Izon products are being developed to meet.